{"product_id":"cst-23833s","title":"CST,  23833S, Senescence beta-Galactosidase Activity Assay Kit (Fluorescence, Plate-Based)","description":"Assay Kit for studying beta-galactosidase bacteria in the research area.\n\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Functional\n\u003cb\u003eBackground\u003c\/b\u003e\nβ-galactosidase (also known as β-gal) is an essential hydrolase enzyme that catalyzes the hydrolysis of galactose-containing carbohydrates into monosaccharides. Substrates of β-galactosides include lactose, various glycoproteins, ganglioside GM1, and lactosylceramides. β-galactosidase is used widely in molecular biology; for example, isolation of recombinant bacteria during molecular cloning utilizes α-complementation of the bacterial β-galactosidase gene ( ) in the presence of a β-gal substrate to identify recombinant clones (1). In cell biology, Senescence-Associated beta-galactosidase (SA-β-gal), defined as β-gal activity at pH 6.0, is a widely used marker of replicative senescence. While initially thought to derive from a unique isoform of β-galactosidase expressed specifically in senescent cells (2), SA-β-gal activity was subsequently shown to result from overexpression and accumulation of β-galactosidase in endogenous lysosomes, and is not specifically required for replicative senescence (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n4-MUG; SA-beta-Gal Substrate; Senescence; Senescence 1X Cell Lysis Buffer; Senescence 2X Reaction Buffer; Senescence Stop Solution","brand":"CST","offers":[{"title":"Default Title","offer_id":46800801267881,"sku":"23833S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-23833s","provider":"Iright","version":"1.0","type":"link"}