CST, 24120S, GIGYF2 Antibody

Polyclonal Antibody for studying TNRC15. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, GIGYF2 Antibody (CST #24120) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody . Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity GIGYF2 Antibody recognizes endogenous levels of total GIGYF2 protein. Species Reactivity: Human Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu355 of human GIGYF2 protein. Antibodies are purified by peptide affinity chromatography. Background GRB10-interacting GYF protein 2 (GIGYF2) is part of a macromolecular protein complex, which also also contains 4EHP, that functions to repress the translation of a distinct subset of mRNAs during embryonic development. Indeed, disruption of 4EHP and GIGYF2 complex formation prevents normal embryonic development in mice (1). Research studies have also demonstrated that GIGYF2 is involved in repressing translation of defective mRNAs, which prevents expression of potentially toxic protein products (2). In addition to its role in repression of protein translation, GIGYF2 may cooperate with the Grb10 adapter protein to regulate signaling of receptor tyrosine kinases (3). Alternate Names GGYF2; GIGYF2; GRB10 interacting GYF protein 2; GRB10-interacting GYF protein 2; GYF2; KIAA0642; PARK11; Parkinson disease (autosomal recessive, early onset) 11; PERQ amino acid rich, with GYF domain 2; PERQ amino acid rich, with GYF domain 3; PERQ amino acid-rich with GYF domain-containing protein 2; PERQ2; PERQ3; TNRC15; Trinucleotide repeat-containing gene 15 protein Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 180 SOURCE: Rabbit