{"product_id":"cst-24201s","title":"CST,  24201S, SIT Antibody","description":"Polyclonal Antibody for studying SIT. Validated for Western Blotting. Highly specific and rigorously validated in-house, SIT Antibody (CST #24201) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nSIT Antibody recognizes endogenous levels of total SIT protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro75 of human SIT protein. Antibodies are purified by peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nSHP2-interacting transmembrane adapter protein (SIT) is a transmembrane glycoprotein that is expressed in lymphocytes as a disulfide-linked homodimer (1). The cytoplasmic domain of SIT contains multiple tyrosine residues, which when phosphorylated upon TCR engagement, recruit signaling molecules that act to negatively regulate T cell activation (1-3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\ngp30\/40; MGC125908; MGC125909; MGC125910; RP11-331F9.5; SHP-2 interacting transmembrane adaptor protein; SHP2 interacting transmembrane adaptor; SHP2-interacting transmembrane adapter protein; SHP2-interacting transmembrane adaptor protein; signaling threshold regulating transmembrane adaptor 1; Signaling threshold-regulating transmembrane adapter 1; SIT; SIT-R; SIT1; suppression inducing transmembrane adaptor 1; Suppression-inducing transmembrane adapter 1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 30-40\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46797778092201,"sku":"24201S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-24201s","provider":"Iright","version":"1.0","type":"link"}