{"product_id":"cst-24209s","title":"CST,  24209S, Lamin B2 (E1S1Q) Rabbit Monoclonal Antibody (HRP Conjugate)","description":"Monoclonal Antibody for studying Lamin B2. Validated for Western Blotting. Highly specific and rigorously validated in-house, Lamin B2 (E1S1Q) Rabbit Monoclonal Antibody (HRP Conjugate) (CST #24209) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 136 mM NaCl, 2.6 mM KCl, 12 mM sodium phosphate (pH 7.4) dibasic, 2 mg\/ml BSA, and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nLamin B2 (E1S1Q) Rabbit Monoclonal Antibody (HRP Conjugate) recognizes endogenous levels of total lamin B2 protein.\nSpecies Reactivity: Human, Mouse, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu75 of human lamin B2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nLamins are nuclear membrane structural components that are important in maintaining normal cell functions, such as cell cycle control, DNA replication, and chromatin organization (1-3). Lamins have been subdivided into types A and B. Type-A lamins consist of lamin A and C, which arise from alternative splicing of the lamin A gene . Lamin A and C are cleaved by caspases into large (41-50 kDa) and small (28 kDa) fragments, which can be used as markers for apoptosis (4,5). Type-B lamins consist of lamin B1 and B2, encoded by separate genes (6-8). Lamin B1 is also cleaved by caspases during apoptosis (9). Research studies have shown that duplication of the lamin B1 gene is correlated with pathogenesis of the neurological disorder adult-onset leukodystrophy (10).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nepididymis secretory sperm binding protein; EPM9; LAMB2; lamin B2; lamin B3; Lamin-B2; LMN2; LMNB2; MGC2721\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M Mk\nSENSITIVITY: Endogenous\nMW (kDa): 68-70\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800362602665,"sku":"24209S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-24209s","provider":"Iright","version":"1.0","type":"link"}