{"product_id":"cst-24276t","title":"CST,  24276T, CLEC2D (E4K1H) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying CLEC2D. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, CLEC2D (E4K1H) Rabbit Monoclonal Antibody (CST #24276) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCLEC2D (E4K1H) Rabbit Monoclonal Antibody recognizes endogenous levels of total CLEC2D protein. Based on the antigen sequence, this antibody is predicted to recognize multiple isoforms of CLEC2D.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human CLEC2D protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nC-type lectin domain family 2 member D (CLEC2D), also known as lectin-like transcript 1 (LLT1) and osteoclast inhibitory lectin (OCIL), is a type II transmembrane C-type lectin receptor primarily expressed upon immune cell activation in T cells, B cells, NK cells, and plasmacytoid and monocyte-derived dendritic cells (1-4). CLEC2D interacts with NKR-P1A (KLRB1, CD161) on NK cells and some subsets of T cells, inhibiting NK cell cytotoxicity while alternatively inducing proliferation and IFNγ production in T cells (2-4). CLEC2D is also expressed by osteoblasts, inhibiting osteoclast formation and bone resorption (5,6). Multiple isoforms of CLEC2D produced by alternative splicing have been identified (7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nC-type lectin domain family 2 member D; C-type lectin related f; C-type lectin superfamily 2, member D; CLAX; CLC2D; CLEC2D; lectin-like NK cell receptor; Lectin-like transcript 1; LLT-1; LLT1; OCIL; osteoclast inhibitory lectin\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 20-30\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797814005929,"sku":"24276T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-24276t","provider":"Iright","version":"1.0","type":"link"}