{"product_id":"cst-24595s","title":"CST,  24595S, CD206\/MRC1 (E6T5J) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying MRC1 mouse. Validated for WB,WB,IP,IHC,IHC,IF,IF. Available in 3 sizes. Highly specific and rigorously validated in-house, CD206\/MRC1 (E6T5J) Rabbit Monoclonal Antibody (CST #24595) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nSimple Western™: 1:10 - 1:50\nImmunoprecipitation: 1:200\nIHC Leica Bond: 1:200 - 1:800\nImmunohistochemistry (Paraffin): 1:200 - 1:800\nImmunofluorescence (Frozen): 1:400 - 1:800\nImmunofluorescence (Immunocytochemistry): 1:400 - 1:1600\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 87887 .\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation, IHC Leica Bond, Immunohistochemistry (Paraffin), Immunofluorescence (Frozen), Immunofluorescence (Immunocytochemistry)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCD206\/MRC1 (E6T5J) Rabbit Monoclonal Antibody recognizes endogenous levels of total CD206\/MRC1 protein. This antibody recognizes mouse CD206\/MRC1 protein and is also reactive with human CD206\/MRC1; however, this antibody is not suggested for immunohistochemical analysis of human tissues. Instead, CD206\/MRC1 (E2L9N) Rabbit mAb #91992 is recommended for IHC analysis of human tissue samples.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of mouse CD206\/MRC1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe mannose receptor (MR\/CLEC13D\/CD206\/MMR\/MRC1\/Macrophage mannose receptor 1) is an endocytic receptor expressed by populations of dendritic cells, macrophages, and nonvascular endothelium (1). The mannose receptor is a heavily glycosylated type I transmembrane protein with three types of extracellular domains and a short carboxy-terminal cytoplasmic domain with no apparent signaling motif (2-4). The extracellular portion of the protein is made up of a CR domain, which binds sulfated glycans, an FNII domain, which binds collagens, and eight C-type lectin domains, which bind carbohydrates containing mannose, fucose, or GlcNAc (4-7). The receptor recycles between the plasma membrane and early endosomes (8). Functions include a role in antigen cross-presentation, clearance of endogenous proteins, pathogen detection, and trafficking through lymphatic vessels (9-12).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAW259686; CD206; Macrophage mannose receptor 1; mannose receptor, C type 1; MMR; MR; Mrc1; OTTMUSP00000012205\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 190-250\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797851918505,"sku":"24595S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-24595s","provider":"Iright","version":"1.0","type":"link"}