{"product_id":"cst-2459s","title":"CST,  2459S, PSMA6 Antibody","description":"Polyclonal Antibody for studying PSMA6. Validated for Western Blotting. Highly specific and rigorously validated in-house, PSMA6 Antibody (CST #2459) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPSMA6 Antibody detects endogenous levels of total PSMA6 protein.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding residue surrounding Arg93 of human PSMA6 protein. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe 20S proteasome is the major proteolytic enzyme complex involved in intracellular protein degradation. It consists of four stacked rings, each with seven distinct subunits. The two outer layers are identical rings composed of α subunits (called PSMAs), and the two inner layers are identical rings composed of β subunits. While the catalytic sites are located on the β rings (1-3), the α subunits are important for assembly and as binding sites for regulatory proteins (4). Seven different α and ten different β proteasome genes have been identified in mammals (5). PA700, PA28, and PA200 are three major protein complexes that function as activators of the 20S proteasome. PA700 binds polyubiquitin with high affinity and associates with the 20S proteasome to form the 26S proteasome, which preferentially degrades polyubiquitinated proteins (1-3). The proteasome has a broad substrate spectrum that includes cell cycle regulators, signaling molecules, tumor suppressors, and transcription factors. By controlling the degradation of these intracellular proteins, the proteasome functions in cell cycle regulation, cancer development, immune responses, protein folding, and disease progression (6-9).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n27 kDa prosomal protein; IOTA; Macropain iota chain; macropain subunit iota; MGC22756; MGC2333; MGC23846; Multicatalytic endopeptidase complex iota chain; p27K; PROS-27; PROS27; prosomal P27K protein; proteasome (prosome, macropain) subunit, alpha type, 6; proteasome 20S subunit alpha 6; Proteasome iota chain; proteasome subunit alpha 6; Proteasome subunit alpha type-6; proteasome subunit alpha1; proteasome subunit iota; PSA6; PSMA6; testicular secretory protein Li 44\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 26\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46797851852969,"sku":"2459S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-2459s","provider":"Iright","version":"1.0","type":"link"}