{"product_id":"cst-2460s","title":"CST,  2460S, AMPA Receptor (GluA2\/3\/4) Antibody","description":"Polyclonal Antibody for studying GluR3\/GluR4\/GluR2. Validated for Western Blotting. Highly specific and rigorously validated in-house, AMPA Receptor (GluA2\/3\/4) Antibody (CST #2460) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nAMPA Receptor (GluA2\/3\/4) Antibody detects endogenous levels of total GluA2\/3\/4 protein. This antibody may also detect GluA1.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser720 of human GluA2. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nAMPA- (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid), kainate-, and NMDA- (N-methyl-D-aspartate) receptors are the three main families of ionotropic glutamate-gated ion channels. AMPA receptors (AMPARs) are comprised of four subunits (GluA 1-4), which assemble as homo- or hetero-tetramers to mediate the majority of fast excitatory transmissions in the central nervous system. AMPARs are implicated in synapse formation, stabilization, and plasticity (1). In contrast to GluA 2-containing AMPARs, AMPARs that lack GluA 2 are permeable to calcium (2). Post-transcriptional modifications (alternative splicing, nuclear RNA editing) and post-translational modifications (glycosylation, phosphorylation) result in a very large number of permutations, fine-tuning the kinetic properties of AMPARs. Research studies have implicated activity changes in AMPARs in a variety of diseases including Alzheimer's, amyotrophic lateral sclerosis (ALS), stroke, and epilepsy (1).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAMPA-selective glutamate receptor 2; AMPA-selective glutamate receptor 3; AMPA-selective glutamate receptor 4; dJ1171F9.1; GluA2; GluA3; GluA4; GluR-2; GluR-3; GluR-4; GluR-B; GluR-C; GluR-D; GluR-K2; GluR-K3; GLUR2; GLUR3; GLUR4; GLUR4C; GLURB; GLURC; GLURD; glutamate ionotropic receptor AMPA type subunit 2; glutamate ionotropic receptor AMPA type subunit 3; glutamate ionotropic receptor AMPA type subunit 4; Glutamate receptor 2; Glutamate receptor 3; Glutamate receptor 4; glutamate receptor C; Glutamate receptor ionotropic, AMPA 2; Glutamate receptor ionotropic, AMPA 3; Glutamate receptor ionotropic, AMPA 4; glutamate receptor subunit 3; glutamate receptor, ionotrophic, AMPA 3; glutamate receptor, ionotrophic, AMPA 4; glutamate receptor, ionotropic, AMPA 2; glutamate receptor, ionotropic, AMPA 3; glutamate receptor, ionotropic, AMPA 4; GRIA2; GRIA3; GRIA4; HBGR2; MRX94; MRXSW; NEDLIB; NEDSGA\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 100\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46797851984041,"sku":"2460S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-2460s","provider":"Iright","version":"1.0","type":"link"}