{"product_id":"cst-24996w2","title":"CST,  24996W2, Phospho-CD79A (Tyr182) (D1B9) Rabbit Monoclonal Antibody (SignalFlex™ Pacific Blue™ Conjugate)","description":"Monoclonal Antibody for studying CD79A (Tyr188) phosphate. Highly specific and rigorously validated in-house, Phospho-CD79A (Tyr182) (D1B9) Rabbit Monoclonal Antibody (SignalFlex\u003csup\u003e™\u003c\/sup\u003e Pacific Blue\u003csup\u003e™\u003c\/sup\u003e Conjugate) (CST #24996) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nSignalFlex™ conjugates are produced using highly validated Cell Signaling Technology ® primary antibodies and conjugation methods that have been rigorously tested, ensuring high-quality conjugates and lot-to-lot consistency. These conjugates are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity. However, they are not tested on specific assays. Optimal dilutions\/concentrations should be determined by the end user. When performing flow cytometry, we recommend using an isotype control conjugate at the same concentration as the antibody conjugate.\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg\/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPhospho-CD79A (Tyr182) (D1B9) Rabbit Monoclonal Antibody (SignalFlex™ Pacific Blue™ Conjugate) recognizes endogenous levels of human CD79A protein only when phosphorylated on Tyr188. This corresponds to Tyr182 of mouse CD79A protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr188 of human CD79A protein. The phosphopeptide sequence is identical to the region surrounding Tyr182 of mouse CD79A protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nAntigen receptors found on the surface of B cells contain a heterodimeric signaling component composed of CD79A and CD79B, also known as Ig α and Ig β, respectively (1,2). Presence of this receptor complex is essential for B cell development and function (3). Together these two proteins and the associated B cell receptor (BCR) initiate intracellular signaling following antigen binding (4,5). An immunoreceptor tyrosine-based activation motif (ITAM) found in the CD79A intracellular region appears to be important for its function (6). Antigen binding precedes formation of the CD79A and CD79B heterodimer and subsequent activation of receptor associated kinases (7). Research has shown that CD79A is a marker for B-lineage lymphoblastic leukemia (8). Additionally, investigators have found that mutations in the ( ) gene are associated with abnormally low levels of functional B cell receptors in some cases of chronic B cell lymphocytic leukemia (9).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nB-cell antigen receptor complex-associated protein alpha chain; CD79A; CD79A antigen; CD79a antigen (immunoglobulin-associated alpha); CD79a molecule; CD79a molecule, immunoglobulin-associated alpha; Ig-alpha; IGA; MB-1; MB-1 membrane glycoprotein; MB1; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated protein\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800364241065,"sku":"24996W2","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-24996w2","provider":"Iright","version":"1.0","type":"link"}