{"product_id":"cst-25249s","title":"CST,  25249S, PPM1G (E7J2F) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying PPM1G. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, PPM1G (E7J2F) Rabbit Monoclonal Antibody (CST #25249) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPPM1G (E7J2F) Rabbit Monoclonal Antibody recognizes endogenous levels of total PPM1G protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg463 of human PPM1G protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nProtein phosphatase magnesium\/manganese-dependent 1 gamma (PPM1G) is a metal-dependent protein phosphatase belonging to the PP2C\/PPM family of Ser\/Thr phosphatases. PPM1G is a ubiquitously expressed enzyme that binds magnesium\/manganese cations in its active center (1). Research studies have demonstrated that PPM1G acts on numerous substrates to participate in a diverse array of biological processes, such as cell cycle control, protein translation, and antiviral innate immune signaling (2-4). In the context of human disease, PPM1G is highly expressed in hepatocellular carcinoma and may contribute to disease by enhancing cell proliferation and migration (5,6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nMGC1675; MGC2870; PP2C-gamma; PP2C, gamma; PP2CG; PP2CGAMMA; PPM1C; PPM1G; PPP2CG; Protein phosphatase 1C; Protein phosphatase 1G; protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform; protein phosphatase 2, catalytic subunit, gamma isoform; protein phosphatase 2C gamma isoform; Protein phosphatase 2C isoform gamma; Protein phosphatase magnesium-dependent 1 gamma; protein phosphatase, Mg2+\/Mn2+ dependent 1G; protein phosphatase, Mg2+\/Mn2+ dependent, 1G\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 72\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797892911273,"sku":"25249S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-25249s","provider":"Iright","version":"1.0","type":"link"}