{"product_id":"cst-25292s","title":"CST,  25292S, CD8 alpha (SK1) Mouse Monoclonal Antibody (InTraSeq™ 3' Conjugate 3030)","description":"Monoclonal Antibody for studying CD8A. Validated for Single Cell Analysis - InTraSeq™ 3'. Highly specific and rigorously validated in-house, CD8 alpha (SK1) Mouse Monoclonal Antibody (InTraSeq\u003csup\u003e™\u003c\/sup\u003e 3' Conjugate 3030) (CST #25292) is ready to ship.\n\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in PBS (pH 7.2), 2 mM EDTA, 0.05% Triton X-100, 2 mg\/mL BSA, and 50% glycerol. Store at -20°C. Do not aliquot the antibody .\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Single Cell Analysis - InTraSeq™ 3'\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCD8 alpha (SK1) Mouse Monoclonal Antibody (InTraSeq™ 3' Conjugate 3030) recognizes endogenous levels of total CD8α protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with human peripheral blood T cells.\n\u003cb\u003eBackground\u003c\/b\u003e\nCluster of Differentiation 8 (CD8) is a disulphide-linked heterodimer consisting of the unrelated α and β subunits. Each subunit is a glycoprotein composed of a single extracellular Ig-like domain, a polypeptide linker, a transmembrane part and a short cytoplasmic tail. On T cells, CD8 is the coreceptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen-Major Histocompatibility Complex (MHC). Specifically, the Ig-like domain of CD8α interacts with the α3-domain of the MHC class I molecule. CD8 ensures specificity of the TCR-antigen interaction, prolongs the contact between the T cell and the antigen presenting cell, and the α chain recruits the tyrosine kinase Lck, which is essential for T cell activation (1).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCD8; CD8 antigen alpha polypeptide; CD8 antigen, alpha polypeptide (p32); CD8A; CD8a molecule; Leu2; Leu2 T-lymphocyte antigen; MAL; OKT8 T-cell antigen; p32; T cell co-receptor; T-cell antigen Leu2; T-cell surface glycoprotein CD8 alpha chain; T-lymphocyte differentiation antigen T8\/Leu-2; T8 T-cell antigen\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nSource\/Isotype: Mouse IgG1","brand":"CST","offers":[{"title":"Default Title","offer_id":46800776036521,"sku":"25292S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-25292s","provider":"Iright","version":"1.0","type":"link"}