{"product_id":"cst-25444t","title":"CST,  25444T, QSER1 (F6Z3K) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying QSER1. Validated for Western Blotting,Immunoprecipitation,Chromatin IP. Available in 2 sizes. Highly specific and rigorously validated in-house, QSER1 (F6Z3K) Rabbit Monoclonal Antibody (CST #25444) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nFor optimal ChIP results, use 10 μL of antibody and 10 μg of chromatin (approximately 4 × 10 6 cells) per IP. This antibody has been validated using SimpleChIP ® Enzymatic Chromatin IP Kits.\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:100\nChromatin IP: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation, Chromatin IP\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nQSER1 (F6Z3K) Rabbit Monoclonal Antibody recognizes endogenous levels of total QSER1 protein. This antibody detects isoform 1 and isoform 2 of QSER1.\nSpecies Reactivity: Human, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser136 of human QSER1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe glutamine and serine-rich protein 1 ( ) gene is located on human chromosome 11. A single nucleotide polymorphism (SNP) near the locus has been associated with older age onset Parkinson's disease through genome-wide association studies (1), and exome sequencing has suggested QSER1 could potentially serve as a marker of type 2 diabetes (2). More recently, it was shown that QSER1 cooperates with TET1 to protect DNA methylation valleys from methylation mediated by DNMT3 (3). Recent reports have also found that QSER1 tends to be upregulated in multiple cancers, and this upregulation is associated with poor clinic outcomes (4,5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nFLJ21924; glutamine and serine rich 1; Glutamine and serine-rich protein 1; QSER1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 250\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797895106729,"sku":"25444T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-25444t","provider":"Iright","version":"1.0","type":"link"}