{"product_id":"cst-25690s","title":"CST,  25690S, Human Insulin-like Growth Factor II (hIGF-II)","description":"Growth Factors and Cytokines for studying IGF2 in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWorking concentration of hIGF-II generally ranges from 1-100 ng\/ml.\n\u003cb\u003eStorage\u003c\/b\u003e\nRecombinant human IGF-II is supplied as lyophilized material that is very stable at -20°C. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg\/ml which can be further diluted in aqueous solutions as needed. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long term storage. Once in solution, store at 4°C and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles if storing reconstituted material at -20ºC to -80ºC.\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nRecombinant human IGF-II was expressed in and is supplied in a lyophilized form.\n\u003cb\u003eBackground\u003c\/b\u003e\nIGF-II is a potent cellular mitogen that is closely related to IGF-I (1). IGF-II is primarily produced by the liver and is frequently overexpressed in tumors (1,2). IGF-II binds to the IGF-IR, activating the AKT, mTOR, ERK, and JNK pathways (1). IGF-II signaling is regulated by several distinct mechanisms. First, IGF binding proteins (IGFBPs) bind to IGF-II and block interactions with the IGF-IR (1-3). Second, the IGF-IIR binds to and acts as a molecular trap for IGF-II (1-3). Lastly, the gene is an imprinted gene, and loss of imprinting leads to increased IGF-II levels (1-3). Aberrant levels of IGF-II are associated with Wilms tumor, Beckwith-Wiedmann syndrome, and colorectal cancer (1,2).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nIGF; IGF-2","brand":"CST","offers":[{"title":"Default Title","offer_id":46800712368297,"sku":"25690S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-25690s","provider":"Iright","version":"1.0","type":"link"}