{"product_id":"cst-25792t","title":"CST,  25792T, SOX5 (E8S4A) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying SOX5. Validated for Chromatin IP. Available in 2 sizes. Highly specific and rigorously validated in-house, SOX5 (E8S4A) Rabbit Monoclonal Antibody (CST #25792) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nFor optimal ChIP results, use 2.5 μL of antibody and 10 μg of chromatin (approximately 4 × 10 6 cells) per IP. This antibody has been validated using SimpleChIP ® Enzymatic Chromatin IP Kits.\nChromatin IP: 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Chromatin IP\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nSOX5 (E8S4A) Rabbit Monoclonal Antibody detects endogenous levels of SOX5 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human SOX5 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nSOX5 is a member of the SOX (SRY-related HMG-box) family of transcription factors. It is involved in the regulation of embryonic development, and specifically essential for driving chondrogenesis (1). In recent years, it has become apparent that SOX5 plays a significant role in the progression of various tumor types, such as breast cancer, glioma, hepatocellular carcinoma, lung cancer, and others (2-5). Upregulation of SOX5 in these tumor types has been reported to drive metastasis through activation of epithelial-mesenchymal transition (EMT) (2-5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nL-SOX5; L-SOX5B; L-SOX5F; LAMSHF; MGC35153; SOX5; SRY (sex determining region Y)-box 5; SRY-box 5; SRY-box transcription factor 5; Transcription factor SOX-5\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800328392873,"sku":"25792T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-25792t","provider":"Iright","version":"1.0","type":"link"}