{"product_id":"cst-2588s","title":"CST,  2588S, DLL1 Antibody","description":"Polyclonal Antibody for studying DLL1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, DLL1 Antibody (CST #2588) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nDLL1 Antibody detects transfected levels of DLL1. This antibody does not recognize transfected levels of rat DLL3 and human DLL4.\nSpecies Reactivity: Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to a region surrounding residue Ala627 of human DLL1. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nNotch signaling is activated upon engagement of the Notch receptor with its ligands, the DSL (Delta, Serrate, Lag2) single-pass type I membrane proteins. The DSL proteins contain multiple EGF-like repeats and a DSL domain that is required for binding to Notch (1,2). Five DSL proteins have been identified in mammals: Jagged1, Jagged2, Delta-like (DLL) 1, 3, and 4 (3). Ligand binding to the Notch receptor results in two sequential proteolytic cleavages of the receptor by the ADAM protease and the γ-secretase complex. The intracellular domain of Notch is released and then translocates to the nucleus, where it activates transcription. Notch ligands may also be processed in a way similar to Notch, suggesting a bi-directional signaling through receptor-ligand interactions (4-6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nDelta; delta like canonical Notch ligand 1; delta-like 1 (Drosophila); delta-like 1 protein; Delta-like protein 1; Delta1; DL1; DLL1; Drosophila Delta homolog 1; epididymis secretory sperm binding protein; H-Delta-1; NEDBAS\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: R\nSENSITIVITY: Transfected Only\nMW (kDa): 82\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46800181428393,"sku":"2588S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-2588s","provider":"Iright","version":"1.0","type":"link"}