{"product_id":"cst-25959t","title":"CST,  25959T, Aspartoacylase (F8X9Z) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying ASPA. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Aspartoacylase (F8X9Z) Rabbit Monoclonal Antibody (CST #25959) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nAspartoacylase (F8X9Z) Rabbit Monoclonal Antibody recognizes endogenous levels of total aspartoacylase protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro102 of human aspartoacylase protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nAspartoacylase (ASPA), also known as aminoacylase-2 (ACY-2), is found primarily in oligodendrocytes and is the only enzyme in the brain that hydrolyzes N-acetyl-l-aspartate (NAA) (1,2). NAA is synthesized from l-aspartate and acetyl-CoA in the neuronal mitochondria of brain gray matter and is one of the most abundant amino acid derivatives found in the vertebrate brain, second only to glutamate (2). NAA levels in the brain must be tightly regulated, with abnormally low levels detected in multiple sclerosis and Alzheimer's disease, and abnormally high levels measured in Canavan disease (3-5). Canavan disease is a fatal neurodegenerative disorder and is the only identified genetic disorder caused by a defect in the processing of a metabolite produced exclusively in the brain (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nACY-2; ACY2; aminoacylase 2; Aminoacylase-2; ASP; ASPA; Aspartoacylase; aspartoacylase (Canavan disease)\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 40\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797934395561,"sku":"25959T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-25959t","provider":"Iright","version":"1.0","type":"link"}