{"product_id":"cst-26013s","title":"CST,  26013S, CD89\/FCAR (F1T9J) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying FCAR. Validated for Western Blotting,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, CD89\/FCAR (F1T9J) Rabbit Monoclonal Antibody (CST #26013) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nImmunohistochemistry (Paraffin): 1:50 - 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 85114 .\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCD89\/FCAR (F1T9J) Rabbit Monoclonal Antibody recognizes endogenous levels of total CD89\/FCAR protein. Non-specific staining was observed in pancreatic acinar cells and apical membrane of colon epithelium by immunohistochemistry.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human CD89\/FCAR protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nImmunoglobulin alpha Fc (IgA Fc) receptor (FcαRI), also known as CD89\/FCAR, is a member of the Fc receptor superfamily and is expressed as a transmembrane glycoprotein on the surface of immune cells of the myeloid lineage (1-3). Research studies have demonstrated that CD89\/FCAR can bind to polymeric IgA-containing immune complexes, which mediates receptor activation, internalization, and signaling (4). Productive signaling by CD89\/FCAR requires association with the FcR gamma-chain and subsequent engagement of the tyrosine kinases, Fyn and Syk, to drive activation of pro-inflammatory signaling cascades (1,5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCD89; CTB-61M7.2; Fc alpha receptor; Fc fragment of IgA receptor; Fc fragment of IgA, receptor for; FcalphaRI; FCAR; FCAR variant 14; IgA Fc receptor; Immunoglobulin alpha Fc receptor\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 60-80\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797934854313,"sku":"26013S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-26013s","provider":"Iright","version":"1.0","type":"link"}