{"product_id":"cst-26081s","title":"CST,  26081S, AP4B1 Antibody","description":"Polyclonal Antibody for studying AP4B1. Validated for Western Blotting. Highly specific and rigorously validated in-house, AP4B1 Antibody (CST #26081) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nAP4B1 Antibody recognizes endogenous levels of total human AP4B1 protein. Weak reactivity has been observed in rodent.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ile708 of human AP4B1 protein. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nAP (adaptor protein) complexes regulate intracellular membrane trafficking along endocytic and secretory pathways (1). There are five AP complexes (AP1-5) that exist as heterotetrameric complexes functioning at distinct intracellular compartments. The AP4 complex, which includes AP4E1, AP4B1, AP4M1, and AP4S1, functions at the -Golgi network (TGN)Â (2-4). AP-4 associates with Atg9A which is critical in autophagosome biogenesis (5). Deficiency in AP-4 led to Atg9A retention within the -Golgi network with defective axonal autophagosome generation (5). AP-4 deficiency has been linked to a group of neurodegenerative diseases known as hereditary spastic paraplegia. Mutation in the gene was identified as a cause for the neurological disorder hereditary spastic paraplegia type 47 (SPG47) (6,7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAdapter-related protein complex 4 subunit beta-1; adaptor related protein complex 4 beta 1 subunit; adaptor related protein complex 4 subunit beta 1; Adaptor-related protein complex 4 subunit beta-1; adaptor-related protein complex 4, beta 1 subunit; AP-4 adapter complex subunit beta; AP-4 adaptor complex subunit beta; AP-4 complex subunit beta-1; AP4B1; beta 4 subunit of AP-4; Beta subunit of AP-4; BETA-4; Beta4-adaptin; CPSQ5; spastic paraplegia 47; SPG47\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 80\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46797935345833,"sku":"26081S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-26081s","provider":"Iright","version":"1.0","type":"link"}