{"product_id":"cst-26402t","title":"CST,  26402T, FcRL3 (E1V4L) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying FcRL3. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, FcRL3 (E1V4L) Rabbit Monoclonal Antibody (CST #26402) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nFcRL3 (E1V4L) Rabbit Monoclonal Antibody recognizes endogenous levels of total FcRL3 protein. This antibody detects a 42 kDa band of unknown origin in some cell lines.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp70 of human FcRL3 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nFcRL3 (Fc receptor-like protein 3, IRTA3, FcRH3) is a member of the Fc receptor-like family of proteins, which show high structural homology to classical Fc receptors in their extracellular domains (1,2). FcRL3 is a type I transmembrane protein, containing a long cytoplasmic tail with one ITAM, one ITIM, and an ITAM-like region (1,2). FcRL3 is primarily expressed in B lymphocytes in lymph nodes and germinal centers, although it has also been found in NK cells and subsets of T cells (1-6). Functional variants of the gene have been associated with autoimmune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), autoimmune thyroiditis, and autoimmune pancreatitis (3-6). FcRL3 has inhibitory potential on BCR-mediated signaling, possibly through the association of ITIMs with phosphatases SHIP, SHP-1, and SHP-2 (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCD307c; Fc receptor homolog 3; Fc receptor like 3; Fc receptor-like 3; Fc receptor-like protein 3; FcR-like protein 3; FCRH3; FCRL3; hIFGP3; IFGP family protein 3; IFGP3; Immune receptor translocation-associated protein 3; immunoglobulin superfamily receptor translocation associated protein 3; IRTA3; SH2 domain-containing phosphatase anchor protein 2; SPAP2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 100, 120\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797937639593,"sku":"26402T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-26402t","provider":"Iright","version":"1.0","type":"link"}