{"product_id":"cst-27072t","title":"CST,  27072T, TWEAK Receptor\/Fn14 (E6N2I) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying TweakR. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, TWEAK Receptor\/Fn14 (E6N2I) Rabbit Monoclonal Antibody (CST #27072) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nTWEAK Receptor\/Fn14 (E6N2I) Rabbit Monoclonal Antibody recognizes endogenous levels of total TWEAK Receptor\/Fn14 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly118 within the cytoplasmic region of human TWEAK Receptor\/Fn14 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe receptor for TWEAK, fibroblast growth factor-inducible 14 (Fn14), is a member of the TNF superfamily of receptors thought to be involved in cell growth, adhesion and migration (1). Its expression is regulated by a number of different growth factors (1,2). Elevated expression is also seen in some cancers including hepatocellular carcinomas (3), glioblastomas (4), and pancreatic cancer (5). The receptor contains a binding site for members of the TNFR-associated factor (TRAF) family that promotes the activation of NF-κB (1,6). Recent studies have suggested some therapeutic potential of TWEAK and its receptor signaling in regards to autoimmunity and cancer treatment (7-9).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCD266; FGF-inducible 14; fibroblast growth factor-inducible immediate-early response protein 14; FN14; TNF receptor superfamily member 12A; TNFRSF12A; TNR12; Tumor necrosis factor receptor superfamily member 12A; Tweak-receptor; tweak-receptor; type I transmembrane protein Fn14; TweakR; type I transmembrane protein Fn14\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 14-17\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797943046313,"sku":"27072T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-27072t","provider":"Iright","version":"1.0","type":"link"}