{"product_id":"cst-2719s","title":"CST,  2719S, beta-IG-H3 Antibody","description":"Polyclonal Antibody for studying betaIG-H3. Validated for Western Blotting,Immunoprecipitation,Immunofluorescence (Immunocytochemistry). Highly specific and rigorously validated in-house, beta-IG-H3 Antibody (CST #2719) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\nImmunofluorescence (Immunocytochemistry): 1:100\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation, Immunofluorescence (Immunocytochemistry)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nbeta-IG-H3 Antibody detects endogenous levels of total βIG-H3 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxyl terminus of human βIG-H3. Antibodies were purified by peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nβIG-H3 (TGFBI\/RGD-CAP\/Kerato-epithelin) is a 683-amino acid secretory protein induced by TGF-β that plays a role in cell adhesion, differentiation, and apoptosis (1-4). βIG-H3 contains an internal cysteine-rich EMI domain followed by four fasciclin-1 domains and a carboxy terminal RGD domain (1,2). It contributes to cell adhesion through interactions with integrins as well as a number of extracellular matrix (ECM) proteins including collagen, fibronectin, and laminin (5-7). ECM βIG-H3 is found in a wide variety of tissues (8-12). Mutations in the βIG-H3 gene as well as elevated protein levels are most notably associated with corneal dystrophies (13).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nBeta ig-h3; beta-IG-H3; beta-IGH3; betaIG-H3; BGH3; BIGH3; CDB1; CDG2; CDGG1; CSD; CSD1; CSD2; CSD3; EBMD; Kerato-epithelin; LCD1; RGD-CAP; RGD-containing collagen-associated protein; TGFBI; transforming growth factor beta induced; transforming growth factor beta-induced 68kDa; Transforming growth factor-beta-induced protein ig-h3; transforming growth factor, beta-induced, 68kD; transforming growth factor, beta-induced, 68kDa\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 70\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46797943701673,"sku":"2719S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-2719s","provider":"Iright","version":"1.0","type":"link"}