{"product_id":"cst-27398s","title":"CST,  27398S, Human FGF-acidic\/FGF1 Recombinant Protein","description":"Growth Factors and Cytokines for studying aFGF in the research area.\n\n\u003cb\u003eStorage\u003c\/b\u003e\nHuman FGF-acidic\/FGF1 Recombinant Protein is supplied as lyophilized material that is very stable at -20°C. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg\/mL which can be further diluted in aqueous solutions as needed. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Once in solution, store at 4°C and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles if storing reconstituted material at -20ºC to -80ºC.\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nRecombinant human FGF-acidic was expressed in and is supplied in a lyophilized form.\n\u003cb\u003eBackground\u003c\/b\u003e\nFGF-acidic (FGF1) is a potent growth factor for fibroblasts and endothelial cells (1). FGF-acidic is involved in wound repair, angiogenesis, and development (1). FGF-acidic is secreted from cells via an endoplasmic reticulum\/Golgi independent mechanism (1,2). The ability of FGF-acidic to bind to heparin sulfate is required for its ability to interact with FGF receptors and induce signaling (1-4). There are four distinct FGF receptors and each has multiple splice variants (1,3). FGF-acidic binds with high affinity to many, but not all, FGFRs (1). Signaling cascades activated through FGF-basic binding to FGFR include the ras-raf-MAPK, PLCγ\/PKC, and PI3K\/Akt pathways (1).","brand":"CST","offers":[{"title":"Default Title","offer_id":46800712532137,"sku":"27398S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-27398s","provider":"Iright","version":"1.0","type":"link"}