{"product_id":"cst-2763t","title":"CST,  2763T, MESDC2 (C22F5) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying MESD2. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, MESDC2 (C22F5) Rabbit Monoclonal Antibody (CST #2763) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nMESDC2 (C22F5) Rabbit Monoclonal Antibody detects endogenous levels of total MESDC2 protein.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a recombinant human MESDC2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nMesoderm development candidate genes 1 (MESDC1) and 2 (MESDC2) were identified from the mesoderm development (MESD) deletion interval located on mouse chromosome 7 (1). MESD acts as a chaperone for low-density lipoprotein receptor (LDLR) proteins in the ER, and particularly associates with Wnt signaling pathway coreceptors LRP5 and LPR6 (2). MESD is required for proper LRP5\/6 folding and maturation to the cell surface, which plays a major role in Wnt signaling (3-5). The interaction between MESD and LRP5 is disrupted by a G171V mutation in LRP5 that is found in individuals with a familial phenotype characterized by high bone mass (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nBOCA; KIAA0081; LDLR chaperone MESD; LRP chaperone MESD; MESD; MESDC2; MESDM; Mesoderm development candidate 2; mesoderm development LRP chaperone; Mesoderm development LRP chaperone MESD; Mesoderm development protein; OI20; Renal carcinoma antigen NY-REN-61\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 25, 26\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46798015332521,"sku":"2763T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-2763t","provider":"Iright","version":"1.0","type":"link"}