{"product_id":"cst-27967s","title":"CST,  27967S, HOXB9 (E7P5O) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying HOXB9. Validated for WB,IP,IF,F. Available in 2 sizes. Highly specific and rigorously validated in-house, HOXB9 (E7P5O) Rabbit Monoclonal Antibody (CST #27967) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:100\nImmunofluorescence (Immunocytochemistry): 1:400 - 1:1600\nFlow Cytometry (Fixed\/Permeabilized): 1:800 - 1:1600\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation, Immunofluorescence (Immunocytochemistry), Flow Cytometry (Fixed\/Permeabilized)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nHOXB9 (E7P5O) Rabbit Monoclonal Antibody recognizes endogenous levels of total HOXB9 protein. This antibody does not cross-react with HOXA9, HOXC9, or HOXD9 proteins.\nSpecies Reactivity: Human, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val116 of human HOXB9 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nis a member of the gene cluster which, along with the , , and gene clusters, governs embryonic patterning along the cranio-caudal axis (1,2). HOXB9 protein functions to regulate formation of the rib cage and contributes to development of the forelimbs (3,4). De-regulation of HOXB9 protein expression is associated with multiple types of cancer. HOXB9 expression is downregulated in pancreatic ductal adenocarcinoma and upregulated in lung adenocarcinoma, where it is associated with poor prognosis (5,6). Overexpression of HOXB9 in breast and hepatocellular carcinomas activates the epithelial-to-mesenchymal transition (EMT) through modulation of TGF-β, promoting tumor progression and metastasis (7,8). HOXB9 overexpression in gliomas increases tumorigenicity by stimulating proliferation, migration, and sphere formation (9).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nhomeo box 2E; homeo box B9; homeobox B9; Homeobox protein Hox-2.5; Homeobox protein Hox-2E; Homeobox protein Hox-B9; HOX-2.5; HOX2; HOX2E; HOXB9; HXB9\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H Mk\nSENSITIVITY: Endogenous\nMW (kDa): 28\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46798017691817,"sku":"27967S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-27967s","provider":"Iright","version":"1.0","type":"link"}