{"product_id":"cst-28020t","title":"CST,  28020T, PRSS15\/LONP1 (D8W1J) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying PRSS15\/LONP1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, PRSS15\/LONP1 (D8W1J) Rabbit Monoclonal Antibody (CST #28020) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPRSS15\/LONP1 (D8W1J) Rabbit Monoclonal Antibody recognizes endogenous levels of total PRSS15\/LONP1 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly887 of human PRSS15\/LONP1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nPRSS15\/LONP1 is an ATP-dependent serine protease that selectively degrades misfolded, misassembled, or damaged proteins in mitochondrial matrix. PRSS15\/LONP1 is induced by hypoxic, proteotoxic, and endoplasmic reticulum (ER) stress to support cell survival (1). It has been reported that PRSS15\/LONP1 inducibility is decreased during aging and chronic stress (2-4). PRSS15\/LONP1 is found to be substantially elevated in lymphoma cells compared to resting or activated B cells, and knock-down or inhibition of PRSS15\/LONP1 induces apoptosis in lymphoma cells (5). Mutation in PRSS15\/LONP1 is associated with CODAS syndrome, a multi-system developmental disorder characterized by cerebral, ocular, dental, auricular, and skeletal anomalies (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCODASS; hLON; hLON ATP-dependent protease; LON; lon peptidase 1, mitochondrial; Lon protease homolog, mitochondrial; Lon protease-like protein; LONHs; LONM; LONP; LONP1; MGC1498; Mitochondrial ATP-dependent protease Lon; mitochondrial lon peptidase 1; mitochondrial lon protease-like protein; PIM1; protease, serine, 15; PRSS15; Serine protease 15\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 106\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46798018052265,"sku":"28020T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-28020t","provider":"Iright","version":"1.0","type":"link"}