{"product_id":"cst-28284s","title":"CST,  28284S, C9orf7\/CACFD1 (E6E3J) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying Flower. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, C9orf7\/CACFD1 (E6E3J) Rabbit Monoclonal Antibody (CST #28284) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nC9orf7\/CACFD1 (E6E3J) Rabbit Monoclonal Antibody recognizes endogenous levels of total human C9orf7\/CACFD1 protein. Based on the antigen sequence, this antibody is predicted to detect isoforms 1 and 2 of C9orf7\/CACFD1 protein, but not isoforms 3 or 4.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu168 of human C9orf7\/CACFD1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nC9orf7\/Calcium Channel Flower Domain Containing 1 (CACFD1), also known as Flower (FWE), is the human homolog of the gene. In , expression of specific FWE membrane protein isoforms indicates the fitness of a cell during clonal selection and cell competition processes, which promotes the elimination of weaker cells from a growing population (1). In humans, there are four isoforms of C9orf7\/CACFD1. Investigators have shown expression of human C9orf7\/CACFD1 isoforms 1 and 3 indicates reduced cellular fitness compared to cells expressing isoforms 2 and 4, which provide a competitive advantage in survival. Moreover, human cancer cells show increased expression of isoforms 2 and 4 that confers a competitive growth advantage for cancer cells. Inhibition of C9orf7\/CACFD1 expression reduces tumor growth and metastasis, and induces sensitivity to chemotherapy (2-5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nC9orf7; CACFD1; calcium channel flower domain containing 1; Calcium channel flower domain-containing protein 1; Calcium channel flower homolog; D9S2135; FLOWER; FLOWR\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 19\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46798053114025,"sku":"28284S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-28284s","provider":"Iright","version":"1.0","type":"link"}