{"product_id":"cst-2843s","title":"CST,  2843S, C\/EBPalpha (p42) Antibody","description":"Polyclonal Antibody for studying C\/EBP-alpha. Validated for Western Blotting. Highly specific and rigorously validated in-house, C\/EBPalpha (p42) Antibody (CST #2843) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nC\/EBPalpha (p42) Antibody detects endogenous levels of total p42 C\/EBPalpha protein but not p30 C\/EBPalpha.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the amino-terminal sequence of human C\/EBPalpha. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nCCAAT\/enhancer-binding proteins (C\/EBPs) are a family of transcription factors that are critical for cellular differentiation, terminal function, and inflammatory response (1). Six members of the family have been characterized (C\/EBPα, β, δ, γ, ε, and ζ) and are distributed in a variety of tissues (1). Translation from alternative start codons results in two isoforms of C\/EBPα (p42 and p30), which are both strong transcriptional activators (2). It has been reported that insulin and insulin-like growth factor-I stimulate the dephosphorylation of C\/EBPα, which may play a key role in insulin-induced repression of GLUT4 transcription (3). Phosphorylation of C\/EBPα at Thr222, Thr226, and Ser230 by GSK-3 seems to be required for adipogenesis (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nC\/EBP alpha; C\/EBP-alpha; CCAAT enhancer binding protein alpha; CCAAT\/enhancer binding protein (C\/EBP), alpha; CCAAT\/enhancer-binding protein alpha; CEBP; CEBPA\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 45\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46798054162601,"sku":"2843S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-2843s","provider":"Iright","version":"1.0","type":"link"}