{"product_id":"cst-28702s","title":"CST,  28702S, PLP1 (E9V1N) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying PLP1. Validated for WB,WB,IHC,IF. Available in 2 sizes. Highly specific and rigorously validated in-house, PLP1 (E9V1N) Rabbit Monoclonal Antibody (CST #28702) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nSimple Western™: 1:10 - 1:50\nImmunohistochemistry (Paraffin): 1:50 - 1:200\nImmunofluorescence (Frozen): 1:100 - 1:400\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 36593 .\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunohistochemistry (Paraffin), Immunofluorescence (Frozen)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPLP1 (E9V1N) Rabbit Monoclonal Antibody recognizes endogenous levels of total PLP1 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human PLP1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nMyelin proteolipid protein (PLP1) corresponds to the majority of myelin proteins in the CNS, providing support to axons and modulating the axonal growth (1). DM20 is the result of the alternative splicing of the gene, which is linked to oligodendrocyte differentiation and survival. The imbalance of PLP1\/DM20 is linked to Pelizaeus-Merzbacher disease (2,3), including mitochondrial damage (4). In addition, PLP1, but not DM20, can enter the mitochondria and participate in the metabolism of cells (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nGPM6C; HLD1; Lipophilin; major myelin proteolipid protein; MMPL; Myelin proteolipid protein; MYPR; PLP; PLP\/DM20; PLP1; PMD; proteolipid protein 1; SPG2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 20-30\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46798056325289,"sku":"28702S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-28702s","provider":"Iright","version":"1.0","type":"link"}