{"product_id":"cst-28704sf","title":"CST,  28704SF, CD46 (D6N7H) Rabbit Monoclonal Antibody (BSA and Azide Free)","description":"Monoclonal Antibody for studying CD46. Validated for Western Blotting,Immunohistochemistry (Paraffin). Highly specific and rigorously validated in-house, CD46 (D6N7H) Rabbit Monoclonal Antibody (BSA and Azide Free) (CST #28704) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nThis product is the carrier free version of product #13241. All data were generated using the same antibody clone in the standard formulation which contains BSA and glycerol. This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT\u0026amp;RUN or CUT\u0026amp;Tag assays. If you require a carrier free formulation for chromatin profiling, please contact us . Optimal dilutions\/concentrations should be determined by the end user. BSA and Azide Free antibodies are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity.\n\u003cb\u003eFormulation\u003c\/b\u003e\nSupplied in 1X PBS (10 mM Na 2 HPO 4 , 3 mM KCl, 2 mM KH 2 PO 4 , and 140 mM NaCl (pH 7.8)). BSA and Azide Free. For standard formulation of this product see product # 13241\n\u003cb\u003eStorage\u003c\/b\u003e\nStore at -20°C. This product will freeze at -20°C so it is recommended to aliquot into single-use vials to avoid multiple freeze\/thaw cycles. A slight precipitate may be present and can be dissolved by gently vortexing. This will not interfere with antibody performance.\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCD46 (D6N7H) Rabbit Monoclonal Antibody (BSA and Azide Free) recognizes endogenous levels of total CD46 protein.\nSpecies Reactivity: Human, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro199 of human CD46 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nComplement Regulatory Protein; Membrane Cofactor Protein (CD46) is a type 1 membrane protein that plays an important inhibitory role in the complement system (1). CD46 exhibits a cofactor activity that promotes inactivation of C3b and C4b by serum factor 1, thereby protecting host (self) cells from complement-dependent cytotoxicity (1,2). The importance of CD46 to complement regulation is underscored by the observation that genetic loss of CD46 leads to development of atypical hemolytic-uremic syndrome (aHUS), a disease characterized by uncontrolled complement activation (2,3). In addition to its role in complement inactivation, CD46 can function as a receptor for selected bacteria and viruses (4), and is reportedly required for proper fusion of spermatozoa to the oocyte membrane during fertilization (5). CD46 is implicated in the development and\/or progression of selected cancer types. For example, research studies show elevated CD46 expression in medulloblastoma tumor samples (6), while CD46 expression has been linked with poor prognosis in breast cancer (7). It has been suggested that upregulation of CD46 may serve to protect cancer cells from complement-dependent cytotoxicity, thereby evading destruction by the immune system (8,9).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAHUS2; antigen identified by monoclonal antibody TRA-2-10; CD46; CD46 antigen, complement regulatory protein; CD46 molecule; CD46 molecule, complement regulatory protein; complement membrane cofactor protein; MCP; measles virus receptor; Membrane cofactor protein; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen); MGC26544; MIC10; TLX; TRA2.10; trophoblast leucocyte common antigen; Trophoblast leukocyte common antigen; trophoblast-lymphocyte cross-reactive antigen\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H Mk\nSENSITIVITY: Endogenous\nMW (kDa): 50-70\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46798056390825,"sku":"28704SF","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-28704sf","provider":"Iright","version":"1.0","type":"link"}