{"product_id":"cst-28716t","title":"CST,  28716T, SRCAP (E9V8O) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying SRCAP. Validated for Western Blotting,Immunoprecipitation,Chromatin IP. Available in 2 sizes. Highly specific and rigorously validated in-house, SRCAP (E9V8O) Rabbit Monoclonal Antibody (CST #28716) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nFor optimal ChIP results, use 10 μL of antibody and 10 μg of chromatin (approximately 4 × 10 6 cells) per IP. This antibody has been validated using SimpleChIP ® Enzymatic Chromatin IP Kits.\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\nChromatin IP: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation, Chromatin IP\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nSRCAP (E9V8O) Rabbit Monoclonal Antibody recognizes endogenous levels of total SRCAP protein.\nSpecies Reactivity: Human, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro911 of human SRCAP protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nSnf2-Related CBP Activator Protein (SRCAP) is an ATPase that exists in a large complex that activates transcription by enhancing CBP activity and by depositing H2A.Z into nucleosomes (1-3). SRCAP can enhance nuclear receptor function along with CARM-1 and GRIP-1 (4). In prostate cancer, SRCAP associates with androgen receptor to control prostate specific antigen expression and increase cell growth (5). During double-stranded break repair, SRCAP is required for DNA-end resection and RAD51 recruitment (6). Mutations in SRCAP result in a developmental disorder called Floating-Harbor syndrome (7,8). SRCAP also plays a role in viral infection as it has been shown to interact with various viral proteins (9,10).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\ndomino homolog 1; Domino homolog 2; DOMO1; EAF1; FLHS; FLJ44499; Helicase SRCAP; KIAA0309; Snf2 related CREBBP activator protein; Snf2-related CBP activator; Snf2-related CBP activator protein; Snf2-related CREBBP activator protein; SRCAP; Swi2\/Snf2-related ATPase homolog, domino homolog 1; SWR1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H Mk\nSENSITIVITY: Endogenous\nMW (kDa): 400\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46798056587433,"sku":"28716T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-28716t","provider":"Iright","version":"1.0","type":"link"}