{"product_id":"cst-2896s","title":"CST,  2896S, p18 INK4C (DCS118) Mouse Monoclonal Antibody","description":"Monoclonal Antibody for studying INK4C, p18. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, p18 INK4C (DCS118) Mouse Monoclonal Antibody (CST #2896) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nThe p18 INK4C (DCS118) Mouse Monoclonal Antibody detects endogenous levels of p18 INK4C protein. This antibody does not cross-react with other proteins of the INK4 family.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with purified recombinant human p18 INK4C protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nCyclin-dependent kinases (CDKs) are activated in part by forming complexes with cyclins. For example, CDK4 and CDK6 associate with the D-type cyclins and phosphorylate the retinoblastoma protein. This phosphorylation is a necessary event for cells to enter S-phase (1). The inhibitors of CDK4 (INK4) family include p15 INK4B, p16 INK4A, p18 INK4C and p19 INK4D. p18 has been shown to function as a haploinsufficient tumor suppressor (2). All INK4 proteins are composed of 32 amino acid ankyrin motifs and selectively inhibit CDK4\/6 activity. Mutational analyses of p18 implicate the third and the amino-terminal portion of the fourth ankyrin repeat in mediating binding to CDK4\/6 (3). The interaction of INK4 family members can be a binary complex with CDK4\/6 or ternary complex with cyclin D-bound CDK4\/6 and ultimately results in the inhibition of cell cycle progression (4,5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCDK6 inhibitor p18; CDKN2C; CDKN6; CDN2C; cyclin dependent kinase inhibitor 2C; cyclin-dependent inhibitor; Cyclin-dependent kinase 4 inhibitor C; Cyclin-dependent kinase 6 inhibitor; cyclin-dependent kinase 6 inhibitor p18; cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4); INK4C; p18; p18-INK4c; p18-INK6\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 18\nSource\/Isotype: Mouse IgG2a","brand":"CST","offers":[{"title":"Default Title","offer_id":46798058061993,"sku":"2896S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-2896s","provider":"Iright","version":"1.0","type":"link"}