{"product_id":"cst-29499t","title":"CST,  29499T, CD48 (D7L8I) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying CD48. Validated for Western Blotting,IHC Leica Bond,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, CD48 (D7L8I) Rabbit Monoclonal Antibody (CST #29499) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nIHC Leica Bond: 1:200\nImmunohistochemistry (Paraffin): 1:400\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 90615 .\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, IHC Leica Bond, Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCD48 (D7L8I) Rabbit Monoclonal Antibody recognizes endogenous levels of total CD48 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human CD48 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nCD48 is a glycosylphosphatidylinositol (GPI) -anchored membrane protein of the signaling lymphocyte activation molecule (SLAM) family, also known as SLAMF2 and BLAST-1. It is constitutively expressed on most hematopoietic cells (not on neutrophils and a subset of long-term hematopoietic stem cells in mice) and can be upregulated under certain conditions like infection (1). Interaction with its low affinity ligand CD2 promotes adhesion and TCR signaling (2,3). Interaction with the high affinity ligand CD244 (2B4) regulates natural killer (NK) and CD8 T cell activation and cytolytic function (4-6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nB-lymphocyte activation marker BLAST-1; BCM1; BCM1 surface antigen; BLAST; BLAST1; CD48; CD48 antigen; CD48 antigen (B-cell membrane protein); CD48 molecule; hCD48; Leukocyte antigen MEM-102; mCD48; MEM-102; Signaling lymphocytic activation molecule 2; SLAM family member 2; SLAMF2; TCT.1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 45-50\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46798061142185,"sku":"29499T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-29499t","provider":"Iright","version":"1.0","type":"link"}