{"product_id":"cst-2959s","title":"CST,  2959S, Erlin-2 Antibody","description":"Polyclonal Antibody for studying Erlin2. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, Erlin-2 Antibody (CST #2959) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nErlin-2 Antibody detects endogenous levels of human erlin-2 protein.\nSpecies Reactivity: Human, Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln315 of mouse erlin-2. Antibodies are purified by peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nErlin-1 and erlin-2 (SPFH1 and SPFH2) are SPFH domain-containing proteins that belong to the prohibitin family (1,2). The N-termal domain of erlin proteins contains ER-targeting sequences responsible for their translocation to the endoplasmic reticulum (ER) (3). In the ER, erlin-1 and erlin-2 specifically associate with the detergent resistant lipid raft microdomain of the membrane (3). Erlin-1 may be involved in dentritic cell activation (4) and erlin-2 has been shown to regulate the ER-associated degradation (ERAD) pathway by interacting with endogenous substrates and resulting in their polyubiquitination and degradation (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nC8orf2; Endoplasmic reticulum lipid raft-associated protein 2; epididymis secretory sperm binding protein; ER lipid raft associated 2; Erlin-2; ERLIN2; ERLN2; MGC87072; NET32; spastic paraplegia 18 (autosomal dominant); SPFH domain family, member 2; SPFH domain-containing protein 2; SPFH2; SPG18; Stomatin-prohibitin-flotillin-HflC\/K domain-containing protein 2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M\nSENSITIVITY: Endogenous\nMW (kDa): 43\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46798061568169,"sku":"2959S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-2959s","provider":"Iright","version":"1.0","type":"link"}