{"product_id":"cst-30253t","title":"CST,  30253T, PALB2 (E9R2W) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying PALB2. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, PALB2 (E9R2W) Rabbit Monoclonal Antibody (CST #30253) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPALB2 (E9R2W) Rabbit Monoclonal Antibody recognizes endogenous levels of total PALB2 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val213 of human PALB2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nPartner and localizer of BRCA2 (PALB2), also known as Fanconi Anemia Complementation Group N (FANCN) protein, is an essential binding partner for BRCA1 and BRCA2 proteins. PALB2 acts as a molecular scaffold for the BRCA1\/BRCA2\/RAD51 DNA repair complex, and functions to help recruit this complex to sites of DNA damage and stimulate RAD51 DNA strand-invasion activity required for D-loop formation (1). PALB2 is a tumor suppressor protein that is required for homologous repair of double-stranded DNA breaks. Mutations in PALB2 (mostly mono-allelic truncations) lead to increased susceptibility to breast, prostate, and pancreatic cancers (2-4). Homozygous mutation of PALB2 leads to FANCN, a disorder affecting all bone marrow elements, resulting in anemia, leukopenia, and thrombopenia (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nDKFZp667I166; DKFZp686E1054; FANCN; FLJ21816; mutant partner and localizer of BRCA2; PALB2; Partner and localizer of BRCA2; PNCA3; truncated partner and localizer of BRCA2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 150\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46798065828009,"sku":"30253T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-30253t","provider":"Iright","version":"1.0","type":"link"}