{"product_id":"cst-30327t","title":"CST,  30327T, CXCL9\/MIG (E6Z5W) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying CXCL9. Validated for Western Blotting,Immunoprecipitation,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, CXCL9\/MIG (E6Z5W) Rabbit Monoclonal Antibody (CST #30327) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\nImmunohistochemistry (Paraffin): 1:100 - 1:400\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier-free (BSA and azide free) version of this product see product # 37438\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation, Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCXCL9\/MIG (E6Z5W) Rabbit Monoclonal Antibody recognizes endogenous levels of total CXCL9\/MIG protein. This antibody does not cross-react with CXCL10, CXCL11, or CXCL2 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to full-length human CXCL9\/MIG protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nC-X-C motif chemokine ligand 9 (CXCL9, MIG) is a soluble chemokine expressed by multiple cell types, such as endothelial cells, monocytes, and tumor cells. The expression of CXCL9 is upregulated in response to proinflammatory cytokines, such as IFN-γ and TNF-α. (1,2). CXCL9 binds to CXCR3, a GPCR that is expressed on the surface of multiple populations of immune cells, particularly exclusively activated T lymphocytes (3). Binding of CXCL9 to CXCR3 promotes T cell chemotaxis and infiltration into sites of inflammation that form in settings such as viral infection and tumorigenesis (4-6). Research studies have demonstrated production of CXCL9 by tumor cells mediates tumor suppression through the recruitment of tumor antigen-specific T cells (7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nC-X-C motif chemokine 9; C-X-C motif chemokine ligand 9; chemokine (C-X-C motif) ligand 9; CMK; crg-10; CXCL9; Gamma-interferon-induced monokine; Humig; MIG; monokine induced by gamma interferon; Monokine induced by interferon-gamma; SCYB9; Small-inducible cytokine B9\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 15\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46798066286761,"sku":"30327T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-30327t","provider":"Iright","version":"1.0","type":"link"}