{"product_id":"cst-30690s","title":"CST,  30690S, INK128","description":"Chemical Modulators for studying in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nINK128 is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.07 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.\n\u003cb\u003eStorage\u003c\/b\u003e\nStore lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles.\n\u003cb\u003eBackground\u003c\/b\u003e\nINK128, also known as MLN0128, is a second-generation active-site mTOR inhibitor (asTORi). Treating cells with INK128 leads to the dephosphorylation of mTOR downstream targets including p70 S6 kinase and 4E-BP1 (1,2). Research has proven that INK128 is an effective mTOR inhibitor because it targets both the mTORC1 and mTORC2 complexes at a high potency (K = 1.4nM) (1). Studies have shown that INK128 has anti-leukemic effects and can induce apoptosis at higher concentrations (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nMLN-0128","brand":"CST","offers":[{"title":"Default Title","offer_id":46800694018217,"sku":"30690S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-30690s","provider":"Iright","version":"1.0","type":"link"}