{"product_id":"cst-30729p","title":"CST,  30729P, Androgen Receptor (E3S4N) Rabbit Monoclonal Antibody (Carboxy-terminal Antigen) (Biotinylated)","description":"Monoclonal Antibody for studying Androgen Receptor. Validated for Peptide ELISA (DELFIA). Highly specific and rigorously validated in-house, Androgen Receptor (E3S4N) Rabbit Monoclonal Antibody (Carboxy-terminal Antigen) (Biotinylated) (CST #30729) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nBiotinylated antibodies are ideal for immunoassay technologies and high-throughput ELISA platforms that require antibody pairs where both antibodies are from the same host. Platforms utilizing biotinylated antibodies include, but are not limited to MSD, xMAP, Quanterix Simoa, AlphaLISA, AlphaScreen, HTRF, LANCE, and TR-FRET. Optimal dilutions\/working concentrations should be determined by the end user. Please contact us if you require the antibody clone biotinylated at a different concentration, a carrier-free formulation, or a more customized packaging solution.\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 140 mM NaCl, 3 mM KCl, 10 mM sodium phosphate (pH 7.4) dibasic, 2 mM potassium phosphate monobasic, 2 mg\/mL BSA, and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nAndrogen Receptor (E3S4N) Rabbit Monoclonal Antibody (Carboxy-terminal Antigen) (Biotinylated) recognizes endogenous levels of total Androgen Receptor protein. This antibody does not detect AR-V7 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val662 of human Androgen Receptor protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nAndrogen receptor (AR), a zinc finger transcription factor belonging to the nuclear receptor superfamily, is activated by phosphorylation and dimerization upon ligand binding (1). This promotes nuclear localization and binding of AR to androgen response elements in androgen target genes. Research studies have shown that AR plays a crucial role in several stages of male development and the progression of prostate cancer (2,3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAIS; ANDR; Androgen receptor; AR; AR8; DHTR; Dihydrotestosterone receptor; HUMARA; HYSP1; KD; NR3C4; Nuclear receptor subfamily 3 group C member 4; SBMA; SMAX1; TFM\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 110\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800375480489,"sku":"30729P","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-30729p","provider":"Iright","version":"1.0","type":"link"}