{"product_id":"cst-3082s","title":"CST,  3082S, C\/EBP beta Antibody","description":"Polyclonal Antibody for studying C\/EBP-beta rat. Validated for Western Blotting. Highly specific and rigorously validated in-house, C\/EBP beta Antibody (CST #3082) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nC\/EBP beta Antibody detects endogenous levels of rat C\/EBPbeta protein. This antibody does not cross-react with other C\/EBP family members such as C\/EBPalpha, -delta, -gamma, -epsilon or -zeta. This antibody also does not recognize the p20 LIP rat C\/EBPbeta isoform.\nSpecies Reactivity: Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser105 of rat C\/EBPbeta. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nCCAAT\/enhancer-binding proteins (C\/EBPs) are a family of transcription factors critical for cellular differentiation, terminal functions, and inflammatory response (1). Six members of the family have been characterized (C\/EBPα, -β, -γ, -δ, -ε, and -ζ) and are distributed in a variety of tissues (1). There are two forms of C\/EBPβ, the 38 kDa liver activating protein (LAP) and the 20 kDa liver inhibitory protein (LIP) which may be products of alternative translation. The 38 kDa LAP protein is a transcriptional activator while LIP may act as an inhibitor of C\/EBPβ transcriptional activity (2). Phosphorylation of C\/EBPβ at distinct sites stimulates its transcriptional activity (3-5). Phosphorylation at serine 105 of rat C\/EBPβ, a unique site only present in the rat sequence, seems essential for rat C\/EBPβ activation (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nC\/EBP beta; C\/EBP-beta; C\/EBP-related protein 2; CCAAT\/enhancer binding protein (C\/EBP), beta; CCAAT\/enhancer-binding protein beta; Cebpb; Crp2; IL-6DBP; Il6dbp; Interleukin-6-dependent-binding protein; LAP; Liver activating protein (LAP also NF-IL6 nuclear factor-IL6 previously designated TCF5); Liver activating protein (LAP, also NF-IL6, nuclear factor-IL6, previously designated TCF5); liver activating protein (LAP); Liver-enriched transcriptional activator; NF-IL6; nuclear factor-IL6; SF-B; Sfb; Silencer factor B; TCF5\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: R\nSENSITIVITY: Endogenous\nMW (kDa): 34 (LAP), 38 (Full Length)\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46800182149289,"sku":"3082S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-3082s","provider":"Iright","version":"1.0","type":"link"}