{"product_id":"cst-30871t","title":"CST,  30871T, CRTAM (F5I5L) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying CRTAM. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, CRTAM (F5I5L) Rabbit Monoclonal Antibody (CST #30871) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCRTAM (F5I5L) Rabbit Monoclonal Antibody recognizes endogenous levels of total CRTAM protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human CRTAM protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nClass I-restricted T cell-associated molecule (CRTAM) is a type I transmembrane glycoprotein that plays a role in T cell development, proliferation, and adhesion (1). CRTAM is transiently expressed on the surface of activated CD8 T cells and natural killer (NK) cells, where it binds to its ligand CADM1 (2,3). CRTAM is also expressed on particular subsets of activated CD4 T cells and is required for the differentiation of CD4 cytotoxic T cells (CTLs) (4-6). CRTAM binding to CADM1 has been shown to enhance the adhesive capacity and cytotoxicity of CD8 T cells and NK cells (2). It also promotes retention and proliferation of CTLs in draining lymph nodes via interaction with CADM1-expressing dendritic cells (DCs) (7). Interestingly, elevated CRTAM expression has been found to be associated with increased survival in patients with triple negative breast cancer (TNBC), suggesting its use as a potential biomarker for immunotherapy efficacy (8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCD355; class I MHC restricted T cell associated molecule; class-I MHC-restricted T cell associated molecule; Class-I MHC-restricted T-cell-associated molecule; CRTAM; cytotoxic and regulatory T cell molecule; Cytotoxic and regulatory T-cell molecule; O95727\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 80\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46798070022313,"sku":"30871T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-30871t","provider":"Iright","version":"1.0","type":"link"}