{"product_id":"cst-30994s","title":"CST,  30994S, CADM1 Antibody","description":"Polyclonal Antibody for studying CADM1. Validated for Western Blotting. Highly specific and rigorously validated in-house, CADM1 Antibody (CST #30994) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCADM1 Antibody recognizes endogenous levels of total CADM1 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human CADM1 protein. Antibodies are purified by peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nCADM1 (cell adhesion molecule 1, TSLC1, Necl-2, IgSF4, SynCAM1) is a member of the immunoglobulin (Ig) cell adhesion superfamily (1). It is a transmembrane protein that is primarily involved in mediating cell-cell adhesion (2,3). CADM1 is comprised of three extracellular Ig-like loops, a transmembrane domain, and a cytoplasmic tail that contains a 4.1 binding motif and a PDZ binding motif. The Ig-like loops contribute to cell-cell junction formation, whereas the cytoplasmic motifs provide structural linkage to the actin cytoskeleton and related adaptor proteins, including actin binding protein 4.1B and membrane-associated guanylate kinases (MAGUKs) (3-5). As an adhesion protein, CADM1 is involved in various biological processes in diverse cells and tissues (6). CADMI functions include structural maintenance and remodeling of epithelium, assembly of neuronal synapses, nerve-mast cell interaction, mast cell behavior, and T cell activation (3,7-9). In many solid tumors, CADM1 has been shown to function as a tumor suppressor by inhibiting malignant proliferation, invasion, and metastasis, while promoting tumor cell apoptosis. In some cases, however, CADM1 has been reported to promote tumor progression (6,10).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nBL2; CADM1; Cell adhesion molecule 1; DKFZp686F1789; IGSF4; IGSF4A; Immunoglobulin superfamily member 4; immunoglobulin superfamily, member 4; immunoglobulin superfamily, member 4D variant 1; immunoglobulin superfamily, member 4D variant 2; MGC149785; MGC51880; NECL-2; NECL2; nectin-like 2; Nectin-like protein 2; RA175; SgIgSF; Spermatogenic immunoglobulin superfamily; ST17; sTSLC-1; Synaptic cell adhesion molecule; SYNCAM; synCAM1; truncated CADM1 protein; TSLC-1; TSLC1; TSLC1\/Nectin-like 2\/IGSF4; Tumor suppressor in lung cancer 1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 100\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46798070448297,"sku":"30994S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-30994s","provider":"Iright","version":"1.0","type":"link"}