{"product_id":"cst-31638t","title":"CST,  31638T, GIGYF2 (E7F7I) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying TNRC15. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, GIGYF2 (E7F7I) Rabbit Monoclonal Antibody (CST #31638) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:100\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nGIGYF2 (E7F7I) Rabbit Monoclonal Antibody recognizes endogenous levels of total GIGYF2 protein.\nSpecies Reactivity: Human, Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser1091 of human GIGYF2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nGrb10-interacting GYF protein 2 (GIGYF2) is part of a macromolecular protein complex, which also contains 4EHP, that functions to repress the translation of a distinct subset of mRNAs during embryonic development. Indeed, disruption of 4EHP and GIGYF2 complex formation prevents normal embryonic development in mice (1). Research studies have also demonstrated that GIGYF2 is involved in repressing translation of defective mRNAs, which prevents expression of potentially toxic protein products (2). In addition to its role in repression of protein translation, GIGYF2 may cooperate with the Grb10 adapter protein to regulate signaling of receptor tyrosine kinases (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nGGYF2; GIGYF2; GRB10 interacting GYF protein 2; GRB10-interacting GYF protein 2; GYF2; KIAA0642; PARK11; Parkinson disease (autosomal recessive, early onset) 11; PERQ amino acid rich, with GYF domain 2; PERQ amino acid rich, with GYF domain 3; PERQ amino acid-rich with GYF domain-containing protein 2; PERQ2; PERQ3; TNRC15; Trinucleotide repeat-containing gene 15 protein\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M\nSENSITIVITY: Endogenous\nMW (kDa): 180\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46798074675369,"sku":"31638T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-31638t","provider":"Iright","version":"1.0","type":"link"}