{"product_id":"cst-31646s","title":"CST,  31646S, TR4\/NR2C2 (E1T8N) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying NR2C2. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, TR4\/NR2C2 (E1T8N) Rabbit Monoclonal Antibody (CST #31646) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody .\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nTR4\/NR2C2 (E1T8N) Rabbit Monoclonal Antibody recognizes endogenous levels of total TR4\/NR2C2 protein.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ile10 of human TR4\/NR2C2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nTesticular receptor 4 (TR4), also called TAK1 or NR2C2, is an orphan receptor in a distinct subclass of the steroid hormone nuclear receptor superfamily along with TR2 (1,2). TR4 forms heterodimers with TR2 and binds to DNA elements containing direct repeats (DRs) (3). TR4 plays a role in various processes, including neurogenesis, spermatogenesis, RNA metabolism, and protein translation (4-6). TR4 can interact with other hormone receptors such as AR and ER to influence protein-protein binding and target gene inactivation (7,8). High expression of TR4 correlates with prostate cancer metastasis and invasion through downstream targets such as CCL2 and Ezh2 (9-10). Expression of TR4 in other cancers such as NSCLC and testicular germ cell tumors has also been associated with poor prognosis (11-12).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nhTAK1; NR2C2; Nuclear hormone receptor TR4; Nuclear receptor subfamily 2 group C member 2; nuclear receptor subfamily 2, group C, member 2; Orphan nuclear receptor TAK1; Orphan nuclear receptor TR4; orphan receptor TR4; TAK1; testicular nuclear receptor 4; Testicular receptor 4; TR2R1; TR4; TR4 nuclear hormone receptor\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 67\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46798074708137,"sku":"31646S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-31646s","provider":"Iright","version":"1.0","type":"link"}