{"product_id":"cst-31793t","title":"CST,  31793T, PLSCR1 (E9B5G) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying PLSCR1. Validated for Western Blotting,Immunoprecipitation,Immunofluorescence (Immunocytochemistry). Available in 2 sizes. Highly specific and rigorously validated in-house, PLSCR1 (E9B5G) Rabbit Monoclonal Antibody (CST #31793) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:200\nImmunofluorescence (Immunocytochemistry): 1:50 - 1:100\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation, Immunofluorescence (Immunocytochemistry)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPLSCR1 (E9B5G) Rabbit Monoclonal Antibody recognizes endogenous levels of total PLSCR1 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human PLSCR1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nPhospholipid scramblase 1 (PLSCR1) is one of four scramblases encoded in the human genome (1). Phospholipid scramblases function to catalyze calcium-mediated ATP-independent mobilization of phospholipids between the inner and outer leaflet of plasma membrane in activated, injured, or apoptotic cells. PLSCR1 is a type II transmembrane protein with a short nine amino acid C-terminal domain and a long N-terminal extracellular domain. Although PLSCR1 is part of a family of proteins that function to catalyze phospholipid mobilization, PLSCR1 may have alternative functions (2,3). Rather, PLSCR1 may function to activate cell signaling pathways, particularly in phagocytic cells of monocyte\/macrophage lineage (4). Microglia, resident macrophages of the brain, play a key role in clearance of cellular and pathologic debris, where altered phagocytosis may contribute to neurodegenerative diseases like Alzheimer's disease. PLSCR1 may regulate microglia phagocytosis, representing a potential therapeutic target to modulate microglia phagocytosis (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCa(2+)-dependent phospholipid scramblase 1; Erythrocyte phospholipid scramblase; MmTRA1b; Phospholipid scramblase 1; PL scramblase 1; PLS1; PLSCR1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 30, 45-100\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800968450217,"sku":"31793T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-31793t","provider":"Iright","version":"1.0","type":"link"}