{"product_id":"cst-32712s","title":"CST,  32712S, TNIK Antibody","description":"Polyclonal Antibody for studying TNIK. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, TNIK Antibody (CST #32712) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nTNIK Antibody recognizes endogenous levels of total TNIK protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg567 of human TNIK protein. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nTRAF2 and NCK-interacting protein kinase (TNIK) is a member of the germinal center kinase (GCK) family (1). TNIK phosphorylates TCF4 and is an essential activator for Wnt signaling (2). Animal knockout model and kinase inhibition studies have reported that TNIK can stimulate both cancer cell growth and epithelial-mesenchymal transition (EMT) (3-5). TNIK has also been shown to promote F-actin disruption through its interactions with Rap2 (6). In neuronal cells, TNIK is enriched in the postsynaptic density (PSD), where it is reported to modulate neuronal receptor surface expression and dendrite complexity and signaling (7-9).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nKIAA0551; MRT54; TNIK; TRAF2 and NCK interacting kinase; TRAF2 and NCK-interacting protein kinase; ZC2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 180\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46800977100969,"sku":"32712S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-32712s","provider":"Iright","version":"1.0","type":"link"}