{"product_id":"cst-32952s","title":"CST,  32952S, Nipah\/Hendra virus Nucleocapsid (F5N9K) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying Hendra henipavirus nucleocapsid. Validated for Western Blotting,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, Nipah\/Hendra virus Nucleocapsid (F5N9K) Rabbit Monoclonal Antibody (CST #32952) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunohistochemistry (Paraffin): 1:400 - 1:1600\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nNipah\/Hendra virus Nucleocapsid (F5N9K) Rabbit Monoclonal Antibody recognizes endogenous levels of total Nipah\/Hendra virus nucleocapsid protein. This antibody has been shown to recognize both Malaysia and Bangladesh strains of Nipah virus.\nSpecies Reactivity: Virus\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nNipah\/Hendra virus Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala530 of Nipah\/Hendra virus nucleocapsid protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nNipah virus (NiV) and Hendra virus (HeV) are highly pathogenic zoonotic paramyxoviruses belonging to the Henipavirus genus. They both possess a non-segmented, negative-sense single-stranded RNA genome, which is tightly encapsidated by the nucleocapsid (N) protein to form a helical ribonucleoprotein (RNP) complex, the fundamental unit for viral RNA synthesis and genome protection (1). The N protein, which is largely conserved between the two viruses, is a major structural component and a key player in its replication cycle. The primary function of the NiV\/HeV N protein is to encapsidate viral genomic and antigenomic RNA. Encapsidation is essential for genome protection, template assembly for RNA synthesis, and nucleocapsid assembly. It also interacts with other viral proteins, such as the viral phosphoprotein (P), which acts as a chaperone for newly synthesized N protein subunits (2). Understanding the structure and function of the NiV and HeV N protein is critical for developing targeted antiviral therapies against this and other highly pathogenic viruses in the Paramyxoviridae family (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nHendra henipavirus N protein; nucleocapsid\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: Vir\nSENSITIVITY: Endogenous (IHC-P), Transfected (W)\nMW (kDa): 65\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800242966697,"sku":"32952S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-32952s","provider":"Iright","version":"1.0","type":"link"}