{"product_id":"cst-32979s","title":"CST,  32979S, AP1S1 (F8K5S) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying AP1S1. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, AP1S1 (F8K5S) Rabbit Monoclonal Antibody (CST #32979) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nAP1S1 (F8K5S) Rabbit Monoclonal Antibody recognizes endogenous levels of total AP1S1 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human AP1S1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe adaptor protein complex 1 (AP-1) is a heterotetrameric protein complex composed of two large adaptins (AP1G1 and AP1B1), a medium adaptin (AP1M1 or AP1M2), and one of several small adaptins (AP3S1, AP1S2, or AP1S3). AP-1 complexes containing AP1M1 are ubiquitously expressed, while complexes containing AP1M2 display a more restricted tissue expression pattern. Research studies have demonstrated that the AP-1 complex is localized to the trans-Golgi network and recycling endosomes where it regulates the bidirectional trafficking of cargo proteins between these subcellular compartments as well as the biogenesis of secretory vesicles (1-3). AP1S1 is one of three possible small adaptin subunits capable of being incorporated into the AP-1 heterotetrameric complex. Mutations in contribute to MEDNIK syndrome, which is characterized by a defect in copper metabolism due to aberrant sorting and trafficking of copper pumps ATP7A and ATP7B (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAdapter-related protein complex 1 sigma-1A subunit; Adaptor protein complex AP-1 sigma-1A subunit; Adaptor protein complex AP-1 subunit sigma-1A; adaptor related protein complex 1 sigma 1 subunit; adaptor related protein complex 1 subunit sigma 1; Adaptor-related protein complex 1 subunit sigma-1A; adaptor-related protein complex 1, sigma 1 subunit; AP-1 complex subunit sigma-1A; AP19; AP1S1; CLAPS1; Clathrin assembly protein complex 1 sigma-1A small chain; Clathrin coat assembly protein AP19; clathrin-associated\/assembly\/adaptor protein, small 1 (19kD); EKV3; FLJ92436; Golgi adaptor HA1\/AP1 adaptin sigma-1A subunit; HA1 19 kDa subunit; MEDNIK; Sigma 1a subunit of AP-1 clathrin; Sigma-adaptin 1A; SIGMA1A; sigma1A subunit of AP-1 clathrin adaptor complex; Sigma1A-adaptin; WUGSC:H_DJ0747G18.2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 18\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800979919017,"sku":"32979S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-32979s","provider":"Iright","version":"1.0","type":"link"}