{"product_id":"cst-33118t","title":"CST,  33118T, TBXAS1 (F4C5I) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying TBXAS1. Validated for Western Blotting,Simple Western™,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, TBXAS1 (F4C5I) Rabbit Monoclonal Antibody (CST #33118) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nSimple Western™: 1:10 - 1:50\nImmunoprecipitation: 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nTBXAS1 (F4C5I) Rabbit Monoclonal Antibody recognizes endogenous levels of total TBXAS1 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human TBXAS1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThromboxane-A synthase (TBXAS1) converts prostaglandin H2 (PGH2) to thromboxane A2 (TXA2) in an isomerization reaction (1). Studies show that TXA2 regulates some cancer development processes, including cell growth, migration, and angiogenesis. In addition, TBXAS1 expression is upregulated in several cancers, suggesting its role in cancer progression and metastasis (2). Furthermore, senescent cells have increased levels of oxylipins. The levels of mRNA, which is involved in oxylipin biosynthesis, are also elevated in some senescent cells (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nBDPLT14; CYP5; CYP5A1; Cytochrome P450 5A1; cytochrome P450, family 5, subfamily A, polypeptide 1; FLJ52771; GHOSAL; platelet, cytochrome P450, subfamily V; TBXAS1; THAS; thromboxane A synthase 1; thromboxane A synthase 1 (platelet); Thromboxane-A synthase; TS; TXA synthase; TXAS; TXS\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 55\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800981033129,"sku":"33118T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-33118t","provider":"Iright","version":"1.0","type":"link"}