{"product_id":"cst-33218s","title":"CST,  33218S, Nicotinamide","description":"Chemical Modulators for studying in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nNicotinamide is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 2.73 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.\n\u003cb\u003eStorage\u003c\/b\u003e\nStore lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles.\n\u003cb\u003eBackground\u003c\/b\u003e\nNicotinamide, a form of vitamin B3, is a NAD+ precursor and inhibitor of sirtuin 1 (SIRT1) with an IC value of \u0026lt;50 uM (1). Nicotinamide is a key component of increasing cell survival and longevity, and plays a critical role in microglial function. It has been shown to prevent apoptosis in neuronal cells and is also a PARP-1 inhibitor, which has been shown to improve cognitive function in Alzheimer's disease patients (2).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nNiacinamide; Nicotinic acid amide; Pyridine-3-carboxylic acid amide; Vitamin B3","brand":"CST","offers":[{"title":"Default Title","offer_id":46800694280361,"sku":"33218S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-33218s","provider":"Iright","version":"1.0","type":"link"}