{"product_id":"cst-33343s","title":"CST,  33343S, NLRC5 (D9Z5X) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying NLRC5. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, NLRC5 (D9Z5X) Rabbit Monoclonal Antibody (CST #33343) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nNLRC5 (D9Z5X) Rabbit Monoclonal Antibody recognizes endogenous levels of total NLRC5 protein. This antibody recognizes isoforms 1-6 of NLRC5 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro131 of human NLRC5 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nNLRC5 (NOD-like receptor family CARD domain containing 5, NOD4, CITA, NOD27) is a member of the NLR family of pattern recognition receptors (PRRs) involved in innate immunity (1,2). NLRC5 is predominantly expressed in hematopoietic cells, and is upregulated by IFN-γ (1-4). NLRC5 transcriptionally regulates the MHC class I antigen presentation pathway, and induces the expression of β2 , and genes, in addition to (3-5). In cancer, NLRC5 is critical for inducing cytotoxic CD8 T cell activity and is a potential target for cancer immune evasion (6,7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCaterpiller protein 16.1; CLR16.1; FLJ21709; FLJ39711; NLR family CARD domain containing 5; NLR family, CARD domain containing 5; NLRC5; NOD-like receptor C5; NOD27; NOD4; Nucleotide-binding oligomerization domain protein 27; Nucleotide-binding oligomerization domain protein 4; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 5; nucleotide-binding oligomerization domains 27; Protein NLRC5\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 205\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800982835369,"sku":"33343S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-33343s","provider":"Iright","version":"1.0","type":"link"}