{"product_id":"cst-33444s","title":"CST,  33444S, Mouse CSF-1\/M-CSF Recombinant Protein","description":"Growth Factors and Cytokines for studying M-CSF mouse in the research area.\n\n\u003cb\u003eStorage\u003c\/b\u003e\nMouse CSF-1\/M-CSF Recombinant Protein is supplied as lyophilized material that is very stable at -20°C. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg\/ml which can be further diluted in aqueous solutions as needed. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Once in solution, store at 4°C and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles if storing reconstituted material at -20ºC to -80ºC.\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nRecombinant mouse CSF-1\/M-CSF was expressed in and is supplied in a lyophilized form.\n\u003cb\u003eBackground\u003c\/b\u003e\nColony stimulating factor 1 (CSF-1)\/macrophage colony stimulating factor (M-CSF) is produced by fibroblasts, endothelial cells, stromal cells, macrophages, osteoblasts, and other cell types (1). CSF-1\/M-CSF is required for growth and differentiation of monocytes and macrophages (1,2). CSF-1\/M-CSF polarizes macrophages into the M2 phenotype where anti-inflammatory IL-10 is produced, rather than the M1 phenotype where inflammatory cytokines are produced. CSF-1\/M-CSF also recruits monocytes and enhances angiogenesis by inducing VEGF production (1,2). CSF-1\/M-CSF binds to its receptor CSF1R; downstream signaling involves PI3K\/Akt, Erk, and Stats 1, 3, and 5 (1,3). An increase in CSF-1\/M-CSF expression may contribute to cancer progression, and high plasma CSF-1\/M-CSF levels are associated with rheumatoid arthritis (1,4,5).","brand":"CST","offers":[{"title":"Default Title","offer_id":46800712794281,"sku":"33444S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-33444s","provider":"Iright","version":"1.0","type":"link"}